A great reminder of best practices I am sure you are all following already! http://technet.microsoft.com/en-us/library/cc973097.aspx

• Creating maintenance plans for Project Server 2010 databases
• Defragmenting indexes for Project Server 2010 databases
• Shrinking databases in Project Server 2010
• Monitoring maintenance plans for Project Server 2010

I know of lot of you are virtualizing our application, this recent article for SharePoint 2010 is a great reminder of best practices for Project Server 2010 as well: http://technet.microsoft.com/en-us/library/hh295699.aspx

1. Use hardware-assisted virtualization
2. Enable hyper-threading on processors that support this technology
3. Configure Non-Uniform Memory Access correctly
4. Configure the Hyper-V host for optimal performance
5. Maintain version compatibility for integration services
6. Determine storage options that are based on virtual machine roles and workloads
7. Configure general virtual machine settings for performance and stability
8. Do not use snapshots in a production environment
9. Design the virtual topology for optimal performance
10. Do not overload the Hyper-V host
11. Do not run resource intensive jobs on the Hyper-V host and virtual machines at the same time

Check out these recent post on the same topic:

• Must read: SharePoint 2010 Virtualization Guidance and Recommendations
• Microsoft Project Server 2010 Virtualization