http://blogs.technet.com/markga/archive/2008/08/26/how-do-you-separate-ocs-administration-between-pools-in-the-same-domain.aspxI had this question today from a large University in the Midwest and after some digging I found the answer to this is yes: Here are the steps to do this: 1) Create two Universal security admin groups in ADUC such as OCSserverPool1group and OCSserverPool2groupen-USCommunityServer 2.1 SP1 (Build: 61025.2)