Zune software
If you read my blog, you know I'm a Zune user (surprise on a microsoft blog). However I honestly believe that subscription music models do change the way that you listen to your music, instead of carefully deciding (especially in present economic conditions) if you really want to buy a CD, you change that to a model where any music you have an interest in or hear about you download and listen to.
Zune does this through the Zune Marketplace, there is a subsciption option with the ZunePass, sub $15 a month and you get to keep 10 songs permanently each month. One of the nice suprises with the ZuneHD release was the upgrade to the Zune 4.0 software and some really nice features.

Some of the really nice features are the SmartDJ (that makes a mix based on some of your music pics) as well as the ability to stream your music to a browser login (Zune Software actually not required)
More Xbox integration coming soon as well