The Microsoft.com operations blog has a fantastic post here describing how they put together a VBscript to check servers for the MyDoom.B Virus when it first came out.
This is a case study on things you can do in the ops room to put out the fire. Worth the read for both Ops types and scripters.
Where else but Microsoft can you get this kind of insider info?
No, seriously, if you know of some place, please leave a comment. Thanks in advance.