After applying May 2014 Cumulative updates for Office 2013 Click-to-Run, an error occurs when refreshing an existing workbook data connection to a .bism file and/or when creating a new connection using a .bism file.
The message received is: "The following System Error occurred: The handle is invalid"
Connect to the data source directly without using the .bism connection file.
Microsoft is aware of and is investigating the issue. We will update this blog as more information is available.
Note: This has been found to occur only with Click-to-Run Office 2013