After applying May 2014 Cumulative updates for Office 2013 Click-to-Run, an error occurs when refreshing an existing workbook data connection to a .bism file and/or when creating a new connection using a .bism file. 

 The message received is:  "The following System Error occurred: The handle is invalid"       

WORKAROUND:

Connect to the data source directly without using the .bism connection file.

STATUS:

Microsoft is aware of and is investigating the issue. We will update this blog as more information is available.

Note:  This has been found to occur only with Click-to-Run Office 2013