Watch this presentation to hear how the team uses System Center Operations Manager to monitor www.microsoft.com as well as other large websites. Brian Copps walks through working with the application development team, Azure monitoring, integration into Service Manager, as well as other best practices -

http://technet.microsoft.com/en-us/edge/how-microsoft-monitors-more-efficiently-with-system-center-operations-manager-2007-r2.aspx