I have listed below which Microsoft technologies are supported by Desire2Learn with the release of 9.2. Since students are prone to financial challenges, many older versions of browsers and operating systems are supported. The recommended versions are bolded below.

Architecture Tier

Product

Operating System

Client

IE 6
IE 7
IE 8
IE 9

Windows 98
Windows 2000
Windows 7 (32 +64 bit)
Windows XP (32 bit)

Windows Vista (32 bit)
Windows Server 2003 (32+64 bit)
Windows Server 2008  (32+64 bit)
Windows Server 2008 R2 (64 bit)

Application Server

IIS 6
Microsoft .Net Framework 1.1
Microsoft .Net Framework 2.0 SP2
Microsoft .Net Framework 3.5 SP1
Windows Server 2003 (32 bit)
Windows Server 2003 R2 (32)

File Server

Windows Server 2003 (32+64 bit)
Windows Server 2003 R2 (32+64 bit)
Windows Server 2008 (32+64 bit) 
Windows Server 2008 R2 (64 bit) 

Database Server

SQL Server 2005 (32 + 64 bit)
SQL Server 2008 (32 + 64 bit)
SQL Server 2008 R2 (32 + 64 bit)
Windows Server 2003 (32+64 bit)
Windows Server 2003 R2 (32+64 bit) 
Windows Server 2008 (32+64 bit) 
Windows Server 2008 R2 (64 bit) 

Server Virtualization

Hyper-V

Windows Server 2008 R2 (64 bit)

Standalone Server

IIS 6
Microsoft .Net Framework 1.1
Microsoft .Net Framework 2.0 SP2
Microsoft .Net Framework 3.5 SP1 
SQL Server 2005 (32 bit)
SQL Server 2008 (32 bit)
SQL Server 2008 R2 (32 bit)

Windows Server 2003 (32 bit)
Windows Server 2003 R2 (32 bit)

You may read a press release on 9.2 here.