Quick Disclaimer: Although this post is intended to be humorous, the following examples are all based off of actual resume problems I have seen. Numerous times. On multiple resumes. Good grief.
Before I get started, if you are actually working on your resume, I strongly recommend the two following articles/blog posts. The advice they give (including the fact that no hiring manager cares about your "Career Objective" statement) are spot on.
In no particular order, I give you:
Programs Used: HP Photosmart Print Driver 5.2.1.63, Windows 3.1, Windows 3.1.1, Windows 95, Windows 95b, Windows 97, Office 4.2.1, Mac OS 6, Oregon Trail, Sheet Metal Scrappings Collector 6.9.1, Adobe Reader, America Online 4.5.6, Prodigy 2.1, CompuServe 3.5, eWorld, Novell Netware 1.6.8, Packard Bell Software Updater 4.3
Where do these lists even come from? Are you running an inventory on the broken computer in the garage? If you haven't used a computer since 1997, maybe Microsoft isn't the place to apply.
However, if you have never actually installed a copy of Windows Server, but you list your experience as "Senior Architectural Consultant who singlehandedly designed an international multi-site Active Directory and Exchange deployment for a Fortune 100 company, with a fault-tolerant backup plan and a 5-nines uptime SLA"… Odds are that the discrepancy will come up in the interview. You will look pretty silly at that point.
When hiring for a position, I want you to succeed. I really do. Stay away from the above mistakes, run the 'ol resume through a spell-check before submitting, and let me see a well-rounded individual with a clear record of career progression and passion for technology. That is the best way to get a follow-up phone call from the recruiter.