Microsoft has announced immediate support for deploying a new Operations Manager 2007 R2 installation with SQL Server 2008 R2. Upgrading your R2 deployment from SQL Server 2005 SP 3 / SQL Server 2008 SP 1 to SQL Server 2008 R2 will be supported with a future cumulative update of Operations Manager 2007 R2.

For details on the steps to perform a new installation, see http://support.microsoft.com/kb/2425714.