The May 11 Security Advisory warns that there is exploit code in the wild for the PNP issue addressed in Microsoft Security Bulletin MS05-039. Bottom line, drop what you are doing and get your W2K desktops patched ASAP.

Read more on the MSRC blog and the Zotob guidance page. This knowledge base article has all the steps needed to help make sure your Windows 2000 computers are automatically kept up to date.