Now that you might have seen the announcement for general availability of Windows 2008 R2 SP1, we wanted to get ahead of the inevitable question: "Is Exchange supported running on Windows Server 2008 R2 SP1?"
We wanted to let you know that we've completed testing with Windows 2008 R2 SP1 and the following versions of Exchange are supported to run on Windows 2008 R2 SP1 (the RTM version of SP1):
Please note that Exchange 2007 was not supported to run on Windows 2008 R2 at all before Exchange 2007 SP3 release.
Also note, Windows 2008 R2 SP1 includes the hotfixes required to install Exchange 2010 SP1 (listed in Exchange 2010 SP1 FAQ and Known Issues — 979744, 983440, 979099, 982867 and 977020). If you're installing Exchange 2010 SP1 on a server running Windows 2008 R2 SP1, you don't need to install these hotfixes separately.
Credits to "Nino Bilic"