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New article in the Exchange 2010 MP online library recently. Read more about it here: http://technet.microsoft.com/en-us/library/ff360301(EXCHG.140).aspx
Taken from the article:
Explanation
This Error event indicates that end-to-end e-mail message flow is taking longer than 90 seconds for more than percent of all messages that have been handled over the previous 30 minutes.
This event may be triggered when one or more of the following conditions are true:
User Action
To resolve this problem, do the following:
If you are not already doing so, consider running the Exchange tools, which have been created to help you analyze and troubleshoot your Exchange environment.