This is actually an open question to you all. :)
It's common for us to say our audience is the IT pro. But "IT pro" is a lazy shortcut to refer to a wide variety of people and positions. Does every IT pro know how to configure and manage permissions for SQL Server databases? Not necessarily, but the IT pro who uses Operations Manager should. So rather than just relying on the amorphous "IT pro" label, I think we should provide a list or overview of the skills and knowledge you need to successfully install and use Operations Manager.
Think about when you first started using Operations Manager -- what did you need to know about SQL Server, IIS, Windows Server, Active Directory, DNS, PowerShell...? About anything? If you were going to hire someone to set up and run Operations Manager in your environment, what skills and knowledge would you expect them to have? Please click "Email Blog Author" over there on the right and let me know your thoughts!
Edited to add: Just to clarify, I'm looking for the expertise with other products and technologies that you need before getting started with Operations Manager.