For the last couple of months I've been running with the Windows 8 Consumer Preview on my laptop.
Besides having to resist the urge to swipe the startup screen (which would be a nice feature even on a standard laptop) the biggest challenge has been to map my previous activities to the Metrofied interface.
However, the following shortcut keys makes that a lot easier:
Windows+X = list of direct shortcuts including CMD (both admin and non-admin), Windows Explorer, Search, Run, Control Panel and Network Connections
Windows+C = brings up the 'right swipe' settings panel
Windows+Q = list of Apps and search function
Windows+W = standard settings
Windows+R = run box
Windows+T = running apps tiles
Windows+I = more settings
Windows+P = projector settings (2nd screen, choose output type, etc).
Windows+L = lock session
Windows+K = 2nd screen output
Windows+H = Share
Windows+F = Files
Windows+D = Desktop
Windows+S = launch snipping tool (for OneNote)
Windows+M = Minimize window
Of these - Windows+X is by far the most useful one and you'll find yourself using it a lot if you're not on a Windows 8 touchpad.