If you create screenshots for use in Word, PowerPoint, or Excel, you can say goodbye to the PrtScn button. Just use the Insert tab's Screenshot button, new in Office 2010:

Screenshot button

Select which open window you want by looking at the thumbnails, and you're done. If you only want to clip part of a screen image, just use the Screen Clipping option, which slides the Office application aside to let you select a portion of the window directly behind it.