A sequenced application, because it runs as a local process, will run on par with native speed (so close it's not worth mentioning).

A few points to mention:-

  1. Startup has two main performance areas:
    a. Time to create the virtual environment
    b. Time to load the application.
        Ensure the application is cached; if not you'll be waiting for blocks to be streamed to the client machine.
  2. If the application excessively uses the registry or it was installed onto the C: drive then performance will be impacted as it causes lots of intercepts for the virtual environment and virtual files system.