We recently uncovered this issue and while we're going to be publishing a Knowledge Base article on it very soon I thought it might be helpful to mention it here as well.
Uninstallation of the Microsoft Application Virtualization 4.6 desktop client may fail with no specific error message given. If you collect a verbose MSI log you may see the following:
SoftGrid Action: IsRuntimePackagePolicyCfgValid Details: NET_DOTIMEOUTMINUTES(#0) is invalid
Also note that you can see this same issue when trying to upgrade a previous version of the App-V client to version 4.6.
This is a known issue with the App-V client versions 4.5 and later.
To resolve this issue you will need to modify the registry entry for the Disconnected Operation Timeout in the registry.
1. For x86 clients, open Regedit and navigate to the following location:
For 64-bit clients, open Regedit and navigate to the following location:
2. Change the DOTimeoutMinutes value to the default which is 129600 (Decimal) or 1fa40 (Hex).
3. Reboot the client.
Once rebooted, you should now be able to successfully uninstall the App-V client.
Steve Thomas | Senior Support Escalation Engineer
Seeing this error trying to install 4.6 sp1 RDS x64 hotfix package 3.
This value is already 129600 so not sure what to do.
See above comment. Changed value to 129601 and the hotfix package 3 applied without error.