We recently noted some of the changes to support for ConfigMgr 2007 over on our support team blog but I wanted to also mention one big App-V 4.6 related change here:
Microsoft Application Virtualization 4.6 is now supported on ConfigMgr 2007 R2 with ConfigMgr 2007 SP2
System Center Configuration Manager 2007 R2 with System Center Configuration Manager 2007 SP2 now supports Microsoft Application Virtualization 4.6 Desktop Client and Client for Remote Desktop Services. This client release enables support for Windows 7 and Windows Server 2008 R2 and support for 64-bit operating systems.
No software updates are required.
If you're curious about what happens if you're not running Service Pack 2 and you upgrade the App-V client to v4.6, the following error is logged in the VirtualApp.log file when trying to register an App-V package with Configuration Manager:
The installed AppVirtMgmt version [4.6] cannot be used with this version of SCCM
It was also reported that you may also get this error in the execmgr.log file:
CVirtualAppExecution::ExecuteProgram - The virtual application package was not registered because the SoftGrid client is not installed
J.C. Hornbeck | System Center Knowledge Engineer