With the release of Microsoft Application Virtualization 4.6 looming on the horizon, a question that seems to pop up over and over again is "Can I run all my apps that I sequenced using App-V 4.5 or 4.2 with the new App-V 4.6 client?" Another one is "Can I run my old 32-bit packages using the new App-V 64-bit client?" The short answer to both is Yes but I have a couple bullet points below that should help clear up some of the confusion:
Note: 4.x includes all version from 4.1 SP1 to current.
Note: New 32-bit applications sequenced with the 4.6 sequencer are NOT supported on 4.5 client as indicated in the support matrix below.
Hope this helps,
J.C. Hornbeck | System Center Knowledge Engineer