Here's another tip from Steve Thomas that he found during the 4.5 beta. This is probably not something you'd run into on a regular basis but I wanted to mention it just in case:
Issue: You may receive the following error message (0e-00002015) when attempting to launch a App-V virtual application by double clicking application OSD file from the Virtual Application Server Content share (e.g. \\SoftGridServer\content\<application>.osd).
Application Virtualization Error The Application Virtualization Client could not launch the application you requested. You are not authorized to perform the selected operation. You must have ‘Add Application’ permissions Error code: 450519-0B20530E-00002015
Cause: This behavior is to be expected if the application in question has never previously been launched on the particular client. Since the application has not been launched at least once before, the client has not yet verified the permissions to the application thus causing the launch to fail.
Resolution: Refresh the Application Virtualization (App-V) 4.5 client in one of the following ways:
J.C. Hornbeck | Manageability Knowledge Engineer
Here's another tip from Steve Thomas that he found during the 4.5 beta.  This is probably not
FW: You receive a 0E-00002015 error when executing a virtual application's OSD for the first time