1st of April could well see the resurgence of the infamous Conflicker or downadup worm which some experts reckoned had infected over 3.5 million computers by January. This is because Conflicker will use a new algorithm to work out which domains to attack.
Many of the problems that have been reported were simply because so many systems were not kept up to date, the critical security update being MS08-67 released on 23rd October 2008. So if you want a quiet relaxing time this week can I suggest that you check the following resources and ensure your systems are in compliance with the advice in them:
There is also advice on the page on how to clean up the mess if you are too late, and the various variants of Conflicker and what to do about them.
It might also be good to let your friends and family know about this so that you can also relax when you get home and the resources they need are here.